Is Gout Hereditary?

is gout hereditary

Gout is a common form of inflammatory arthritis that is known for its intensely painful attacks.1 Long referred to as “the disease of kings,”2 many people and even some healthcare professionals associate gout with excess—specifically, eating and drinking too much.3 Unfortunately, the stigma (and often shame) that can be associated with the disease prevent many patients from seeking the medical help they need.3 But does diet cause gout? Or is gout hereditary?

 

Understanding gout

Gout is caused by a buildup of uric acid in the bloodstream, a medical condition called hyperuricemia.4 As the amount of uric acid rises above normal levels, it can begin to form sharp, needlelike crystals.1 These crystals can cause episodes of sudden and intense pain, swelling, redness and/or extreme tenderness in the affected joint called attacks or flares.1

 

Your risk of gout

Perhaps you have a parent or grandparent who suffered with gout. Maybe you remember watching your loved one experience painful gout attacks. You may worry that you will eventually suffer the same fate. But how can you know if you will develop gout?

A number of gout risk factors can contribute to development of the disease, including your gender, your age, certain medications and other health problems you might have.5 For years it has been known that genetics and diet also play a part in gout development.1,4,5 However, new research shows that the relationship between genetics and gout may actually be stronger than the relationship between diet and gout.6-8

 

New research

A 2018 meta-analysis of the genetics and eating habits of more than 16,000 healthy American adults showed that the impact of genetics on the risk of developing gout was much greater than that of diet.6 Tanya Major, PhD, of the University of Otago in New Zealand and her colleagues reported that even the foods most closely associated with gout—beer, red meat and certain types of seafood, to name a few—accounted for less than 1 percent of the difference in the study patients’ uric acid levels. Genetics, on the other hand, accounted for nearly 24 percent.6

According to Dr. Major, “Our results challenge widely held community perceptions that hyperuricemia is primarily caused by diet, showing that genetic variants have a much greater contribution to hyperuricemia in the general population than dietary exposure.”6

The results of two recent Japanese and Taiwanese studies (Higashino, Takada, Nakaoka, et al; 2017 and Chang and Chen, et al; 2018) provide further evidence supporting the connection between genetics and gout.7,8

 

The importance of a healthy lifestyle

Unfortunately, you can’t change your genes. But here’s some good news: There are things you can do to work toward a healthy lifestyle, including:

  • Maintaining a healthy weight—Maintaining a healthy weight may make it easier for your body to rid itself of excess uric acid.1
  • Drinking more water—Research has shown that drinking more water can reduce your risk of gout flares.9
  • Following a gout-friendly diet—Although diet does not appear to have quite the impact on uric acid levels that genetics does, it is nevertheless important to eat healthfully.6 Choose moderate portions of healthy foods that are lower in purines.6 Fruits, vegetables, whole grains, lean meat and poultry and low-fat dairy products are good options.9

 

Talk with your doctor

If you’re concerned about your risk of gout or suspect that you might be having gout symptoms, talk with your doctor. To help you start the conversation, consider downloading and completing the Gout Flare Questionnaire (from Resources for Patients) before your appointment.

 

NOTE: This article was not written by a medical professional and is not intended to substitute for the guidance of a physician. These are not Hikma’s recommendations for gout flare prevention, but rather facts and data collected from various reliable medical sources. For a full list of resources and their attributing links, see below.

References

  1. Gout/Symptoms & causes. Mayo Clinic website. Available at: https://www.mayoclinic.org/diseases-conditions/gout/symptoms-causes/syc-20372897. Accessed 3/25/19.
  2. More on gout: Once kingly, now common. Harvard Health Publishing/Harvard Medical School website. Available at: https://www.health.harvard.edu/newsletter_article/more-on-gout-once-kingly-now-common. Accessed 3/25/19.
  3. Nicola Dalbeth and Keith J Petrie: It’s time to change the name of gout. The British Medical Journal Opinion/Comment and opinion from the BMJ’s international community of readers, authors, and editors. Available at: https://blogs.bmj.com/bmj/2018/02/05/nicola-dalbeth-and-keith-j-petrie-its-time-to-change-the-name-of-gout/. Accessed 3/25/19.
  4. All about gout. Harvard Health Publishing/Harvard Medical School website. Available at: https://www.health.harvard.edu/newsletter_article/all-about-gout". Accessed 3/25/19.
  5. Gout: Symptoms, Diagnosis & Treatment. What Causes Gout? NIH Medline Plus website. Available at: https://medlineplus.gov/magazine/issues/winter12/articles/winter12pg20.html. Accessed 3/25/19.
  6. Major TJ, Topless RK, Dalbeth N, Merriman TR. Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts. BMJ. 2018;363:k3951.
  7. Higashino T, Takada T, Nakaoka H, et al. Multiple common and rare variants of ABCG2 cause gout. RMD Open. 2017;3:e000464.
  8. Chang S-J, Chen C-J, et al. ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study. Nature/Scientific Reports. 2018;8:3137.

Important Safety Information for Mitigare® (colchicine) 0.6 mg capsules

  • Colchicine 0.6 mg capsules are contraindicated in patients with renal or hepatic impairment who are currently prescribed drugs that inhibit both P-gp and CYP3A4. Combining these dual inhibitors with colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal colchicine toxicity. Patients with both renal and hepatic impairment should not be given Mitigare®.
  • Fatal overdoses have been reported with colchicine in adults and children. Keep Mitigare® out of the reach of children.
  • Blood dyscrasias such as myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, and aplastic anemia have been reported with colchicine used in therapeutic doses.
  • Monitor for toxicity and if present consider temporary interruption or discontinuation of colchicine.
  • Drug interaction with dual P-gp and CYP3A4 inhibitors: Co-administration of colchicine with dual P-gp and CYP3A4 inhibitors has resulted in life-threatening interactions and death.
  • Neuromuscular toxicity and rhabdomyolysis may occur with chronic treatment with colchicine in therapeutic doses, especially in combination with other drugs known to cause this effect. Patients with impaired renal function and elderly patients (including those with normal renal and hepatic function) are at increased risk. Consider temporary interruption or discontinuation of Mitigare®.
  • The most commonly reported adverse reactions with colchicine are gastrointestinal symptoms, including diarrhea, nausea, vomiting, and abdominal pain.

Indication

Mitigare® is indicated for prophylaxis of gout flares in adults. The safety and effectiveness of Mitigare for acute treatment of gout flares during prophylaxis has not been studied.

Mitigare® is not an analgesic medication and should not be used to treat pain from other causes.

For Full Prescribing Information please CLICK HERE and for Medication Guide CLICK HERE.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Manufactured by: West-Ward Columbus Inc., Columbus, OH 43228

Important Safety Information for Mitigare® (colchicine) 0.6 mg capsules

  • Colchicine 0.6 mg capsules are contraindicated in patients with renal or hepatic impairment who are currently prescribed drugs that inhibit both P-gp and CYP3A4. Combining these dual inhibitors with colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal colchicine toxicity. Patients with both renal and hepatic impairment should not be given Mitigare®.
  • Fatal overdoses have been reported with colchicine in adults and children. Keep Mitigare® out of the reach of children.